盐酸二甲双胍 Metformin hydrochloride 1115-70-4
盐酸二甲双胍
1,1-二甲基双胍盐酸盐;盐酸二甲双胍对照品;二甲双胍盐酸盐;盐酸二甲双胍(USP美国药典标准品);二甲双胍原料格列本脲原粉;二甲基双胍;盐酸二甲双胍(标准品);METFORMINHYDROCHLORIDE盐酸二甲双胍
Metformin hydrochloride
1,1-dimethyl-biguanidhydrochloride;diabefagos;diformin;dimethylbiguanidehydrochloride;Dimethyldiguanidinehydrochloride;GLUCOPHAGE;DIABETOSAN;DIABEX
1115-70-4
C4H12ClN5
165.62
1.36[at 20℃]
223-226 °C(lit.)
9℃
Soluble in water (50 mg/ml), ethanol, and DMSO (50 mM).
Freely soluble in water, slightly soluble in alcohol, practically insoluble in acetone and in methylene chloride
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
0.001Pa at 25℃
2-8°C
功能主治：用于轻症糖尿病
本品为降血糖药。本品可降低Ⅱ型糖尿病患者空腹及餐后高血糖，HbAlc可下降1%～2%，本品降血糖的机制可能是：①增加周围组织对胰岛素的敏感性，增加胰岛素介导的葡萄糖利用。②增加非胰岛素依赖的组织对葡萄糖的利用，如脑、血细胞、肾髓质、肠道、皮肤等。③抑制肝糖原异生作用，降低肝糖输出。④抑制肠壁细胞摄取葡萄糖。
